As a gynecologist focused on women’s whole-body health, I’ve seen firsthand how GLP-1 receptor agonists—like semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound)—are changing the landscape of medicine. While most people associate GLP-1s with weight loss, the science reveals something far more exciting: these medications offer profound benefits beyond the scale.
GLP-1s lower inflammation, improve endothelial function, and reduce cardiovascular events—independent of weight loss. Women, especially postmenopausal, often face increased cardiac risk, and GLP-1s may offer protective benefits even in those without diabetes. The cardiovascular data on these drugs is robust, especially in reducing stroke and heart attack risk.
Many of my patients, even those with normal weight, are surprised to learn they have fatty liver—a condition driven by insulin resistance. GLP-1s have been shown to reduce liver fat and improve liver enzyme levels. In women going through perimenopause or menopause, where metabolism often shifts, this can be particularly protective.
Emerging research suggests GLP-1s may have neuroprotective effects. Some studies show slowed cognitive decline in people with Alzheimer’s or Parkinson’s disease. While more research is needed, the link between metabolic health and brain health is becoming increasingly clear—and GLP-1s are right at the center of that conversation.
The hormonal shifts of perimenopause often worsen insulin resistance, increase visceral fat, and destabilize blood sugar levels. GLP-1s can help regulate these metabolic changes, supporting steadier energy, mood, and appetite. For women who can’t take hormone replacement therapy—or need additional support—GLP-1s can be a powerful adjunct.
In women with PCOS or unexplained infertility, regulating insulin and inflammation can improve ovulation and egg quality. Several fertility specialists are now integrating GLP-1s into preconception protocols for select patients to enhance outcomes.
GLP-1s impact the brain’s satiety centers, helping curb sugar cravings and emotional eating. Many of my patients report a new sense of freedom around food—not from willpower, but from biology working in their favor. This isn’t about restriction; it’s about realignment.
GLP-1s are not a “magic shot,” and they’re not right for everyone. But when prescribed thoughtfully—alongside lifestyle and hormonal support—they can be transformative. As a gynecologist who approaches health through the lens of root cause and whole-woman care, I see GLP-1s as tools with profound potential: to restore balance, prevent chronic disease, and support women through every hormonal transition.
If you're curious whether this therapy might be right for you, let’s talk. Your body deserves solutions that are as dynamic and multidimensional as you are.
