As a physician who focuses on optimizing women’s health across the lifespan, I am often asked which supplements are truly worth considering. One that consistently rises to the top is creatine monohydrate. Although long associated with male athletes and bodybuilding, high-quality research demonstrates that creatine offers a wide range of benefits for women—benefits that extend far beyond the gym.
Creatine is a naturally occurring compound synthesized in the liver, kidneys, and pancreas from amino acids (arginine, glycine, and methionine). It is also obtained from animal proteins such as red meat and fish. Once produced or consumed, creatine is stored primarily in skeletal muscle as phosphocreatine.
Phosphocreatine serves as a rapid energy reserve to regenerate adenosine triphosphate (ATP), the energy currency of our cells. During exercise, this system allows muscles to contract at higher intensities for longer periods. Importantly, creatine also supports energy production in the brain, making its benefits systemic, not just muscular.
Supplementation improves strength, power, and endurance when paired with resistance or interval training.
Women often worry creatine will cause bulky muscle growth; in reality, it promotes lean, toned muscle and helps counteract age-related muscle loss (sarcopenia).
Bone density is a critical concern for women, especially after menopause when estrogen declines accelerate bone loss.
Studies show that creatine, combined with resistance exercise, may enhance bone strength by increasing muscle pull on bone and influencing cellular signaling involved in bone remodeling.
Creatine supplementation has been associated with improvements in memory, processing speed, and mood regulation.
It may be especially beneficial in conditions of higher energy demand or metabolic stress—such as during sleep deprivation, pregnancy, or perimenopause—when women often report “brain fog.”
Creatine improves cellular hydration, decreases markers of inflammation, and accelerates recovery between workouts.
Many women notice less post-exercise soreness, allowing them to maintain consistent training without overtraining injuries.
During pregnancy recovery, perimenopause, and menopause, women face increased risks of muscle and bone loss, weight gain, and fatigue.
Creatine offers a safe, evidence-based strategy to support metabolism, strength, and energy during these transitions.
Creatine is one of the most extensively studied dietary supplements, with decades of safety data. It is well tolerated when used as recommended.
Women with kidney disease or other chronic medical conditions should consult their physician before beginning creatine supplementation.
Creatine should not be viewed as a “bodybuilding supplement” but rather as a metabolic enhancer and longevity tool. From supporting bone and muscle health to improving cognitive resilience, creatine has broad applications that align closely with women’s health priorities.
In my practice, I find creatine particularly valuable for:
When paired with a balanced diet, resistance training, and lifestyle interventions, creatine can be a powerful adjunct in promoting vitality and healthspan for women of all ages.
Key Takeaway: Creatine is safe, affordable, and one of the most scientifically supported supplements available. For women, it offers unique benefits across physical performance, bone health, cognitive function, and recovery—making it a cornerstone supplement worth serious consideration.
